Here, a potent adaptive immune response, which includes Th2 cells, and B cells secreting IgE and IgG1, soon develops during helminth infection of mice. Helminths damage tissue during feeding and migration in the intestine, which in turn can trigger the release of danger associated molecular patterns (DAMPs) and cytokine alarmins (interleukin (IL) 25, thymic stromal lymphopoietin (TSLP), and IL 33). These alarmins then activate innate lymphoid cells and likely other cell populations that support the development of a type 2 innate immune response, which in turn provides necessary signals for the development of type 2 adaptive immunity.
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